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目的探讨CEA和CA199在胃癌诊断和临床病理分期中的临床应用。方法选取胃癌患者79例,根据有无手术治疗分为手术组(n=48)和未手术组(n=31),选取正常体检患者(对照组)50例和胃良性疾病作为参照,观察对照组、良性疾病组和胃癌组患者CA199和CEA水平及各项指标。结果对照组CA199和CEA水平最低,良性疾病组和胃癌组患者的CA199和CEA水平逐渐增高(P<0.01);手术前后CA199和CEA水平与手术前相比明显降低,有显著的统计学差异(P<0.01);而手术组患者的CA199和CEA水平随着分期的增加,CA199和CEA水平不断增加,有显著的统计学差异(P<0.01);手术组和未手术组胃癌患者术前年龄、CA199和CEA水平相比无明显的统计学差异(P>0.05)。结论 CEA和CA199水平可作为胃癌诊断、临床病理分期、疗效评价和预后评估的重要指标。
Objective To investigate the clinical application of CEA and CA199 in gastric cancer diagnosis and clinicopathological staging. Methods Totally 79 patients with gastric cancer were divided into operation group (n = 48) and non-operation group (n = 31) according to the presence or absence of operation. 50 patients with normal physical examination (control group) and benign gastric diseases were selected as reference. Group, benign disease group and gastric cancer group CA199 and CEA levels and various indicators. Results The levels of CA199 and CEA in the control group were the lowest, while the levels of CA199 and CEA in the benign disease group and gastric cancer group were gradually increased (P <0.01). The levels of CA199 and CEA before and after the operation were significantly lower than those before operation, with significant statistical difference (P <0.01). However, the levels of CA199 and CEA in patients in operation group increased with the increase of staging and the levels of CA199 and CEA increased significantly (P <0.01). The preoperative age of gastric cancer patients in operation group and non-operation group There was no significant difference between CA199 and CEA levels (P> 0.05). Conclusions The levels of CEA and CA199 can be used as an important indicator of gastric cancer diagnosis, clinical and pathological staging, efficacy evaluation and prognosis evaluation.