An inhibitor of HIF-αsubunit expression suppresses hypoxiainduced dedifferentiation of human NSCLC i

来源 :世界医学遗传学杂志 | 被引量 : 0次 | 上传用户：juezhan2010

【摘要】

：

ferentiation of non-small cell lung cancer(NSCLC)cells and whether a hypoxia-inducible factor(HIF)inhibitor is able to suppress the process.METHODS:Human lung a

【作者】

：

Miho Akimoto Hideko Nagasawa H

【机构】

：

DepartmentofLifeScience,LaboratoryofPharmaceuticalandMedicinalChemistry,DepartmentofLifeSystem

【出处】

：

世界医学遗传学杂志

【发表日期】

：

2013年4期

【关键词】

：

Non-small cell lung CANCER Tumor microenvironment HYPOXIA Hypoxia-inducible FACT

【基金项目】

：

Supported by Grant-in-Aid from the Ministry of Education,Culture,Sports,Science and Technology,(No.18590280),the Foundation for the Promotion of Cancer Research in Japan,Grant-in-Aid for Japan Arterio

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ferentiation of non-small cell lung cancer(NSCLC)cells and whether a hypoxia-inducible factor(HIF)inhibitor is able to suppress the process.METHODS:Human lung adenocarcinoma A549 cells and squamous carcinoma QG56 cells were cultured under normoxic(21%O2)o

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