目的筛选和鉴定B淋巴细胞刺激因子(BLyS)的抑制性小肽。方法用重组人BLyS筛选噬菌体构象型7肽库,人工合成小肽鉴定其免疫抑制功能。结果经过筛选,得到两个阳性噬菌体克隆,人工合成的两个小肽在体外能特异性地抑制BLyS刺激细胞增生的活性。结论获得了两个能够抑制BlyS功能的小肽。 Objective To screen and identify small inhibitory peptides of B lymphocyte stimulating factor (BLyS). Methods Recombinant human BLyS was used to screen phage conformational 7-peptide library and synthetic small peptides to identify its immunosuppressive function. Results After screening, two positive phage clones were obtained. The two small peptides synthesized in vitro could specifically inhibit the proliferation of BLyS stimulated cells in vitro. Conclusion Two small peptides that can inhibit the function of BlyS were obtained.