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心康宁(Trimetazidine dihydrochloride),化学名1-(2,3,4-三甲氧基)哌嗪二盐酸盐,用于治疗急慢性冠状动脉功能不全、心绞痛、心肌梗塞和冠状动脉硬化症等疾病。合成路线有二:其一为:我们采用第二条路线进行合成,文献报导甲酰化收率为71%,经改变反应温度和反应时间,可提高到83%。缩合收率文献报导为38%,我们经过摸索,收率在32～46%。成品经有机元素定量分析、红外光谱分析、质谱分析,均与文献报道相符。
Trimetazidine dihydrochloride, chemical name 1- (2,3,4-trimethoxy) piperazine dihydrochloride for the treatment of acute and chronic coronary insufficiency, angina pectoris, myocardial infarction and coronary atherosclerosis and other diseases . There are two synthetic routes: one is: we use the second route for synthesis, reported in the literature formylation yield of 71%, by changing the reaction temperature and reaction time, can be increased to 83%. Condensation yield reported 38% of the literature, we after exploration, the yield was 32 to 46%. Finished by the organic element quantitative analysis, infrared spectroscopy, mass spectrometry, are in line with the literature.