目的:优选芪术鼻喷雾剂最佳澄清工艺。方法:以毛蕊异黄酮葡萄糖苷含量、总黄酮含量、澄清度为评价指标,选择最佳澄清工艺,并进行优化。结果:芪术鼻喷雾剂优选澄清工艺为:采用醇沉方法澄清处理,药液相对密度为1.05,醇沉浓度为60%,搅拌速度为300r/min。结论:优选的澄清工艺合理可行,重复性好,适用于工业化生产。 Objective: To optimize the best technology of Qi nasal spray. Methods: With the evaluation of the content of glucoside, the content of total flavonoids and the clarity of calycosin, the optimal clarification process was selected and optimized. Results: The optimized technology of Qi Shu nasal spray was as follows: the alcohol sediment was clarified, the relative density of drug solution was 1.05, the alcohol sediment concentration was 60% and the stirring speed was 300r / min. Conclusion: The preferred clarification process is reasonable and feasible with good repeatability and is suitable for industrial production.