论文部分内容阅读
目的:分析Ig A型肾小球肾炎患者的临床病理特征与临床用药。方法:选取2011年2月—2014年2月间病理科收治的Ig A型肾小球肾炎患者56例作为研究对象,采用免疫荧光显微镜、电子显微镜以及光镜检查,并采用中西医结合治疗,分析其临床病理和用药治疗。结果:Ig A型肾小球肾炎患者5种病理分级与其24 h尿蛋白定量间存在相关性,经比较其差异有统计学意义(P<0.05);患者经过中西医结合用药后,部分症状得到有效缓解;采用中医治疗的中成药,雷公藤多苷片的使用患者为最高(41.07%),采用西药治疗的免疫抑制剂患者为26.79%和血管紧张素转化酶抑制剂患者为23.21%。结论:Ig A型肾小球肾炎患者的5种病理分级与其肾功能的改变之间存在相关性;其诊断主要依靠Ig A免疫荧光染色、毛细血管内是否增殖以及经电镜检查示上皮电子致密沉积;采用中西医结合用药治疗的临床效果较佳,症状在一定程度上得到改善。
Objective: To analyze the clinicopathological features and clinical use of IgA glomerulonephritis patients. Methods: Fifty-six patients with IgA glomerulonephritis admitted from February 2011 to February 2014 were enrolled in this study. Immunofluorescence microscopy, electron microscopy and light microscopy were used in this study. Analysis of its clinical pathology and medication. Results: The five pathological grading of IgA glomerulonephritis showed a significant correlation with the 24 h urinary protein (P <0.05). After the treatment with traditional Chinese medicine and western medicine, some symptoms were found (41.07%). The number of immunosuppressants treated with western medicine was 26.79% and the patients with angiotensin-converting enzyme inhibitor were 23.21%. Conclusion: There is a correlation between the five pathological grading of patients with IgA glomerulonephritis and the changes of renal function. The diagnosis mainly depends on IgA immunofluorescence staining, proliferation in capillaries and electron dense deposition by electron microscopy ; The use of traditional Chinese and Western medicine treatment of clinical effect is better, the symptoms improved to some extent.