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本研究用免疫组织化学方法研究了ｒａｓ癌基因产物ｐ￣２１蛋白在５８例人肺癌中的表达。结果表明：ｐ￣２１蛋白在鳞癌中最高，达８１．５％（２２／２７），在腺癌中较低，为６５．２％（１５／２３），２例大细胞癌和１例腺鳞癌均为阳性，５例小细胞肺癌均为阴性，提示ｐ￣２１蛋白是非小细胞肺癌的一个较好标志物。在高分化肺癌，ｐ￣２１蛋白表达的阳性率为８７．５％（１２／１４），在中、低分化的肺癌，则分别为７５．０％（１８／２４）和６６．７％（１０／１５），三者之间无显著差异（Ｐ＞０．０５），提示ｐ￣２１蛋白和肺癌分化的关系尚需进一步研究。
In this study, immunohistochemistry was used to study the expression of ras oncogene product p ̄21 in 58 human lung cancers. The results showed that p ̄21 protein was highest in squamous cell carcinoma, reaching 81.5% (22/27), lower in adenocarcinoma, 65.2% (15/23), 2 cases of large cell carcinoma and 1 case. Adenosquamous carcinoma was positive, 5 cases of small cell lung cancer were negative, suggesting that p ̄21 protein is a good marker of non-small cell lung cancer. In well-differentiated lung cancer, the positive rate of p ̄21 protein expression was 87.5% (12/14). In moderately and poorly differentiated lung cancers, it was 75.0% (18/24) and 66.7% ( 10/15), there was no significant difference between the three (P>0.05), suggesting that the relationship between p ̄21 protein and lung cancer differentiation needs further study.