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本文概述了抑素、多胺、蛋白质水解酶的性质、与细胞增殖调节的关系及其在肿瘤细胞恶性增殖中的可能作用。抑素是一类重要的细胞增殖抑制因子,多胺则可促进细胞增殖,蛋白质水解酶对细胞表面蛋白质的作用也可能是促进细胞分裂的一个因素。抑素活性的降低、多胺合成的加速及蛋白质水解酶活性的增强均与肿瘤细胞的增殖失调有一定的关系。本文最后讨论了患癌动物体液中存在着一类非免疫性抑癌因子的可能性。
This article summarizes the relationship between the properties of somatostatin, polyamines, proteolytic enzymes, and cell proliferation regulation and their possible role in the malignant proliferation of tumor cells. Inhibin is an important class of inhibitors of cell proliferation. Polyamines promote cell proliferation. The effect of proteolytic enzymes on cell surface proteins may also be a contributing factor to cell division. The decrease of somatostatin activity, the acceleration of polyamine synthesis and the enhancement of proteolytic enzyme activity all have a certain relationship with the proliferation of tumor cells. Finally, we discuss the possibility of a class of non-immune tumor suppressor in body fluids of cancer-bearing animals.