吲■甙-(吲羥β-葡萄糖甙)是从新鲜大青叶、板兰根中提取的,经抗病毒试验,知道有一定活性。本所还做了该化合物代谢产物的研究,为研究其作用机制,参考了雷伯特桑(Rebertson)的方法,以KOH为缩合剂,将1-溴四醋酰葡萄糖-C_6~(14)与3-羥基吲(口朶)-2-羧酸甲酯在丙酮溶液中缩合,经皂化、脱醋酰基、脱羧醋酰化和醇解作用得到吲(口朶)甙-C_6~(14)。文献报导吲(口朶)甙合成的最后一步为氨解法。此法反应时间长,副产品醋酸酰胺不易除去,产品也不易纯 Indole-glycosides - (Indohydrox-β-glucoside) is from fresh Folium, Radix extract, the antiviral test, we know that there is a certain activity. In order to study its mechanism of action, we also used Rebertson’s method to synthesize 1-bromo tetraacetylglucose-C_6 ~ (14) with KOH as condensing agent, (Indole) -2-carboxylic acid methyl ester was condensed with acetone solution, and then saponified, decarboxylated, decarboxylated and acylated to obtain indole (C7) . Reported indole (oral) glycosides synthesis of the final step for the ammonia solution. This method reaction time is long, by-product acetic acid amide is not easy to remove, the product is not easy to pure