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目的观察脑苷肌肽注射液(国产神经节苷脂GM1)治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法2004年8月至2006年4月北京朝阳医院儿科对NICU收治的70例新生儿HIE患儿随机分为两组,治疗组(n=36)使用脑苷肌肽治疗,与对照组(n=34)使用胞二磷胆碱或1,6-二磷酸果糖治疗,通过比较两组患儿临床神经症状恢复时间及新生儿行为神经评分(NBNA)来判断药物的疗效。结果脑苷肌肽与胞二磷胆碱或1,6-二磷酸果糖治疗新生儿HIE的疗效差异无显著性意义(P>0.05),均能在7~10d使神经症状恢复正常,在生后2周NBNA评分绝大多数在正常范围内。结论早期应用脑苷肌肽治疗新生儿HIE有良好疗效。
Objective To observe the effect of Eosinoside (GM1) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Seventy neonates with HIE admitted to NICU from August 2004 to April 2006 in Beijing Chaoyang Hospital were randomly divided into two groups. The treatment group (n = 36) was treated with cerebroside, and the control group (n = 34) Treatment with citicoline or fructose-1,6-diphosphate was evaluated by comparing the time to recovery of neurological symptoms and the neonatal behavioral neurological score (NBNA) in both groups. Results There was no significant difference in the therapeutic effect of cinoside and citicoline or fructose-1,6-diphosphate on neonates with HIE (all P> 0.05), all of which returned to normal after 7-10 days. After birth, The 2 weeks NBNA score most of the normal range. Conclusion Early application of encephalitoside in the treatment of neonatal HIE has a good effect.