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目的探讨偶极子定位方法在药物难治性癫痫术前致痫灶定位研究中的作用和准确性。方法对30例药物难治性癫痫患者的致痫灶进行术前偶极子定位,术中以皮层及深部电极加以验证,依据验证结果比较继发性癫痫和原发性癫痫偶极子定位的准确性,并对病灶、致痫灶进行手术处理,术后随访并分别比较继发性癫痫和原发性癫痫的手术治疗效果。结果偶极子对继发性癫痫致痫灶定位的准确性要高于原发性癫痫,经卡方检验,x±s=12.470,P=0.001统计学有显著性差异;两者的治疗结果,P=0.143差异没有显著性。结论偶极子定位是一种无创性的致痫灶定位方法,对继发性癫痫术前致痫灶定位准确,手术效果满意;对原发性癫痫或致痫灶多发、弥散,偶极子定位技术存在一定的局限性。
Objective To investigate the role and accuracy of dipole localization in the study of the localization of epileptic foci before drug-refractory epilepsy. Methods Preoperative dipole localization was performed on the epileptogenic zone in 30 patients with drug-refractory epilepsy. The operation was verified by the cortex and deep electrodes during the operation. The secondary epilepsy and primary epilepsy dipole localization were compared based on the verification results Accuracy, and lesions, epileptogenic lesions were treated, postoperative follow-up and were compared with surgical treatment of secondary epilepsy and primary epilepsy. Results The accuracy of location of dipole in epileptic foci of secondary epilepsy was higher than that of primary epilepsy. According to the chi-square test, there was statistically significant difference between x ± s = 12.470 and P = 0.001. The treatment results of the two , P = 0.143 difference was not significant. Conclusions Dipole localization is a noninvasive method of locating epileptic foci. It is accurate in preoperative epileptic foci of secondary epilepsy and satisfactory in its surgical results. It is also effective in treating primary epilepsy or epileptogenic lesions with multiple, diffuse, dipolar Positioning technology has some limitations.