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大黄的泻下作用在中医古代文献中早有记载。我们在以往研究的基础上,进一步观察了大黄对肠管内水份及电解质的影响,以探讨其泻下作用的原理。实验方法一、肠道内容物推进功能和排出时间的测定见以往报导。二、肠道内水份和电解质移行速度按Gordon-Chadwick(1979)体内环封法稍加改良测定。实验时,采用雄性大白鼠,体重300克左右。动物经腹腔麻醉后于右下腹开口约3～4厘米,暴露盲肠,找到回盲瓣,将回盲口下端进行结扎,然后在盲肠端开一小口,
The purgative effect of rhubarb has been documented in ancient Chinese literature. Based on previous studies, we further observed the effects of rhubarb on water and electrolytes in the intestine to explore the principle of diarrhea. Experimental methods I. Measurement of intestinal propulsion function and discharge time See previous reports. Second, the intestinal water and electrolyte migration rate according to Gordon-Chadwick (1979) slightly modified by the internal ring closure method. In the experiment, male rats were used and they weighed about 300 grams. After anesthesia, the animals were opened approximately 3 to 4 cm in the right lower abdomen, exposed the cecum, found the ileocecal valve, and then ligated the lower end of the ileocecal opening, and then opened a small mouth in the cecum.