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目的分析浙江省中年居民体质指数(BMI)、腰围身高比(WHtR)及膳食脂肪摄入情况与血清瘦素水平的相关性。方法采用分层随机抽样法,于2014年12月从浙江省抽取4个区县513名30~65岁调查对象,采用3天24小时膳食回顾法进行膳食调查,同时测量其身高、体重、腰围及血清瘦素浓度,分析体格指标及膳食脂肪与瘦素的关系。结果女性血清瘦素水平高于男性(P<0.001)。BMI、WHtR与瘦素水平均呈正相关,相关系数男性和女性分别为0.488、0.576和0.453、0.333(P<0.0001)。调整WHtR后女性BMI与瘦素水平仍有相关性(r=0.321,P<0.0001),调整BMI后男性WHtR与瘦素水平仍有相关性(r=0.354,P<0.0001),其余指标相关性消失。偏最小二乘回归结果显示男性WHtR(β=0.27)标准化偏回归系数高于BMI(β=0.21),而女性则为BMI(β=0.26)高于WHtR(β=0.20)。男性总能量、总脂肪、单不饱和脂肪酸(MUFA)与瘦素水平呈负相关(P<0.05),而女性多不饱和脂肪酸(PUFA)供能比及(PUFA+MUFA):SFA与瘦素水平呈正相关(P<0.05)。对男性调整WHtR、对女性调整BMI,可见男性总脂肪、MUFA仍与瘦素呈负相关(P<0.05);女性PUFA供能比与瘦素呈正相关(P<0.05),其余指标相关性消失。结论肥胖程度与瘦素水平呈正相关关系,在评价肥胖与瘦素水平关系时,男性WHtR与瘦素水平相关性更强,女性BMI与瘦素水平相关性更强;男性总脂肪摄入量、MUFA与瘦素水平呈负相关,女性PUFA供能比与瘦素水平呈正相关。
Objective To analyze the correlation between body mass index (BMI), waist circumference ratio (WHtR), dietary fat intake and serum leptin level among middle-aged residents in Zhejiang province. Methods Taken stratified random sampling method from 513 counties of 4 districts and counties in Zhejiang Province from December 2014 to December of 2003, the survey was conducted using a 24-hour three-day dietary review method. The height, weight, waist circumference And serum leptin concentrations, analysis of physical indicators and the relationship between dietary fat and leptin. Results Serum leptin levels were higher in women than in men (P <0.001). BMI, WHtR and leptin levels were positively correlated, the correlation coefficient of male and female were 0.488,0.576 and 0.453,0.333 (P <0.0001). There was still a correlation between BMI and leptin level after adjustment for WHtR (r = 0.321, P <0.0001). There was still a correlation between WHtR and leptin level after adjustment for BMI (r = 0.354, P <0.0001) disappear. Partial least squares regression showed that the normalized partial regression coefficient of WHtR was higher in men than in BMI (β = 0.21), while in women it was higher for BMI (β = 0.26) than for WHtR (β = 0.20). Male total energy, total fat, monounsaturated fatty acids (MUFA) and leptin levels were negatively correlated (P <0.05), while PUFAs (PUFA + PUFA) Level was positively correlated (P <0.05). Male WHR adjusted, female adjusted total fat, male total fat, MUFA is still negatively correlated with leptin (P <0.05); female PUFA energy ratio was positively correlated with leptin (P <0.05), the remaining indicators disappeared . Conclusions There is a positive correlation between obesity and leptin levels. In evaluating the relationship between obesity and leptin, the correlation between WHtR and leptin is stronger in male and the correlation between BMI and leptin is stronger in male. The total fat intake, There was a negative correlation between MUFA and leptin level, but there was a positive correlation between PUFA energy supply and leptin level.