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目的：探索藻酸双酯钠（ＰＳＳ）治疗急性乙型肝炎的疗效，并与丹参或山莨菪碱加维生素Ｋ１作比较。方法：Ａ组５６例（男性４４例，女性１２例；年龄３３±ｓ１３ａ）用ＰＳＳ０．１ｇ。Ｂ组５４例（男性４１例，女性１３例；年龄３２±１１ａ）用复方丹参２０ｍＬ。Ｃ组５４例（男性４３例，女性１１例，年龄２９±１３ａ）用氢溴酸山莨菪碱４０ｍｇ加维生素Ｋ１３０ｍｇ。３组药物均分别溶于１０％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，疗程均为７￣１０ｄ。结果：Ａ组血液粘度、血细胞聚集指数、微循环滞留时间、血栓形成系数均较治疗前明显下降（Ｐ＜０．０１）；丙氨酸转氨酶和血清胆红素恢复正常天数均快于Ａ和Ｂ２组。结论：ＰＳＳ不仅有显著改善微循环作用，且降低转氨酶、消退黄疸疗效优于Ｂ，Ｃ２组。
Objective: To investigate the efficacy of sodium alginate (PSS) in the treatment of acute hepatitis B and compare with Salvia miltiorrhiza or anisodamine plus vitamin K1. Methods: A group of 56 patients (44 males and 12 females; age 33 ± s13a) with PSS0.1g. B group 54 (41 males, 13 females; age 32 ± 11a) with compound Danshen 20mL. Group C, 54 patients (43 males, 11 females, age 29 ± 13a) with anisodamine hydrobromide 40mg plus vitamin K130mg. 3 groups of drugs were dissolved in 10% glucose solution 500mL intravenous infusion, qd, treatment were 7 ~ 10d. Results: The blood viscosity, hemagglutination index, microcirculation residence time and thrombosis index in group A were significantly lower than those before treatment (P <0.01), and the days of alanine aminotransferase and serum bilirubin recovery were faster than A and B2 group. Conclusion: PSS not only significantly improve the microcirculation, but also reduce the transaminase, jaundice is better than the B, C2 group.