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目的 :探讨血管内皮生长因子 - C(VEGF- C) m RNA在正常口腔粘膜、白斑及鳞癌等组织中的表达。方法 :RT- PCR法检测 VEGF- C m RNA的表达。结果 :鳞癌组织 VEGF- C m RNA表达明显高于正常口腔粘膜及白斑 (P <0 .0 1) ;鳞癌表达与病理分级 (P <0 .0 1)、淋巴结转移 (P <0 .0 1)密切相关 ,与临床分期无关 (P >0 .0 5 )。结论 :VEGF- C对鳞癌的生长及转移有促进作用 ,有望作为检测淋巴管转移及判断预后的指标之一。
Objective: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) m RNA in normal oral mucosa, leukoplakia and squamous cell carcinoma. Methods: The expression of VEGF-C m RNA was detected by RT-PCR. Results: The expression of VEGF-C m RNA in squamous cell carcinoma was significantly higher than that in normal oral mucosa and leukoplakia (P <0.01). The expression of squamous cell carcinoma and pathological grade (P <0.01) and lymph node metastasis (P <0. 0 1), which was not related to clinical stage (P> 0.05). Conclusion: VEGF-C can promote the growth and metastasis of squamous cell carcinoma, which is expected to be one of the indicators for detecting lymphatic metastasis and prognosis.