消化道恶性肿瘤病人的生存时间决定于肿瘤的生物学特点及肿瘤的分期目前,临床普遍采用的肿瘤分期是TNM分期。而研究表明,除TNM分期外,还有一些独立的预后判断指标值得关注如周围神经浸润(perineural invasionPNI)等。肿瘤的周围神经浸润是指肿瘤细胞侵犯局部邻近的神经的神经束 The survival time of patients with gastrointestinal cancer depends on the biological characteristics of the tumor and tumor staging At present, the most commonly used clinical staging is TNM staging. Studies have shown that, in addition to TNM staging, there are some independent prognostic indicators worthy of attention, such as perineural invasionPNI. Peripheral nerve infiltration of the tumor refers to the nerve bundles in which the tumor cells encroach upon the local, proximal nerves