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目的 :测定青光眼患者血清及房水一氧化氮 (NO)浓度并探讨其在青光眼发病中的作用。方法 :应用硝酸还原酶法测定各型青光眼患者 (实验组 )及白内障患者 (对照组 )血清及房水NO浓度。结果 :两组患者血清NO浓度无统计学差异 (P >0 .0 5 ) ;实验组各青光眼类型之间血清NO浓度无差异 (P >0 .0 5 ) ;实验组房水NO浓度高于对照组(P <0 .0 1 ) ,原发性开角型青光眼房水NO浓度低于对照组及其它类型青光眼组 ,闭角型青光眼房水NO浓度较对照组显著升高 (P <0 .0 1 )。结论 :开角型青光眼由于房角原生型一氧化氮合成酶(NOS)的减少引起房水NO浓度的降低 ,导致房水外流阻力增大 ,眼压升高可引起闭角型青光眼患者房水NO浓度升高 ,损伤小梁网及邻近的葡萄膜和视网膜组织
Objective: To determine the concentration of nitric oxide (NO) in serum and aqueous humor of patients with glaucoma and to explore its role in the pathogenesis of glaucoma. Methods: Nitric acid reductase method was used to determine NO concentration in serum and aqueous humor of various types of glaucoma patients (experimental group) and cataract patients (control group). Results: There was no significant difference in serum NO levels between the two groups (P> 0.05). There was no difference in serum NO concentration between experimental groups and glaucoma groups (P> 0.05) Compared with the control group (P <0.01), the NO level in aqueous humor of primary open-angle glaucoma was lower than that of the control group and other types of glaucoma group (P <0 01) .0 1). CONCLUSIONS: Open angle glaucoma leads to a decrease of NO concentration in aqueous humor due to the reduction of NO in the corner of the angle. This results in increased resistance to aqueous outflow and elevated intraocular pressure which can cause aqueous humor in patients with angle-closure glaucoma Increased NO concentrations damage trabecular meshwork and adjacent uveal and retinal tissues