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在冶金工业中,接触钒油燃烧产物、钒烟和钒尘对作业工人健康的危害早已引起人们的极大关注。已证明动物染钒后,中枢神经系统出现损害,但其作用机理尚未完全阐明。一些研究者报道,谷胱甘肽和巯基能保护机体免遭自由基或过氧化的组织损伤;已知一些重金属对巯基酶亦无竞争抑制作用。本文目的在于确定钒的神经毒性是否反映在大鼠脑组织巯基含量的明显变化。使用150～200g的刚成年雄性大鼠,按
In the metallurgical industry, exposure to vanadium oil combustion products, vanadium smoke and vanadium dust on the health of workers has long been caused by the great concern. It has been shown that after the animals are dyed with vanadium, the central nervous system is damaged, but its mechanism of action has not yet been fully elucidated. Some researchers report that glutathione and thiol can protect the body from free radical or peroxidation of tissue damage; some heavy metals are also known to have no competitive inhibition of thiolases. The purpose of this paper is to determine whether the neurotoxicity of vanadium is reflected in the significant changes in thiol content in rat brain tissue. Use 150 ~ 200g of fresh adult male rats, press