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目的 :研究应用洛赛克针剂 (进口 )、奥美拉唑针剂 (国产 )和硫糖铝片防治危重症患者应激性溃疡的效果。方法 :15 6例患者分为 3组 :第 1组 (n =34)应用洛赛克针剂 (进口 ) 4 0mg ,2次 /d ,静脉点滴 ,3d天后改为洛赛克胶囊 10mg ,1次 /d ,连服 10d。第 2组 (n =6 4 )应用注射用奥美拉唑 (国产 ) 4 0mg ,2次 /d点滴 ,连续 14d。第 3组 (n =5 8)应用硫糖铝 0 .75 g ,3次 /d ,鼻饲 ,连续 14d。结果 :经统计学处理 ,3组治疗总有效率 80 .1% ,但 3组之间疗效有显著差异 (P <0 .0 5 )。结论 :本组危重病应激性溃疡的总发生率 19.9% ,应用洛赛克针剂 (进口 )治疗效果较好。
Objective: To study the effect of using Losec injection (imported), omeprazole injection (domestic) and sucralfate in the prevention and treatment of stress ulcer in critically ill patients. Methods: Fifteen six patients were divided into three groups: group 1 (n = 34) was given Losec injection (imported) 40mg, 2 times / d, intravenous drip, 3d days later changed to Losec capsules 10mg, 1 / d, even serving 10d. Group 2 (n = 6 4) application of omeprazole for injection (domestic) 40mg, 2 times / d, for 14d. Group 3 (n = 5 8) application of sucralfate 0 .75 g, 3 times / d, nasal feeding, continuous 14d. Results: After statistical analysis, the total effective rate of the three groups was 80.1%, but there was significant difference between the three groups (P <0.05). Conclusion: The total incidence of stress ulcer in this group is 19.9%. The treatment with Losec injection (import) is better.