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在哮喘的异常炎性反应中,细胞毒T淋巴细胞相关抗原4(CTLA-4)参与组成T淋巴细胞激活所必需的协同共刺激途径,起负性调节作用。本文以我国北方地区哮喘患儿和正常儿童为研究对象,探讨CTLA-4启动子-318(C/T)基因多态性与哮喘病情及血清总IgE水平的关系。1对象与方法1.1对象采用简
In the abnormal inflammatory response of asthma, cytotoxic T lymphocyte associated antigen 4 (CTLA-4) is involved in the co-costimulatory pathway necessary for the formation of T lymphocyte activation, and plays a negative regulatory role. The aim of this study is to investigate the relationship between CTLA-4 promoter-318 (C / T) gene polymorphism and asthma and serum total IgE in asthmatic children and normal children in northern China. 1 objects and methods 1.1 object Jane