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氟尿嘧啶(5-FU)是对移植性肿瘤具有生长抑制作用的第一个嘧啶类抗代谢物。在临床癌症化疗中,5-FU主要用于治疗胃肠道、肝、胰、乳腺和卵巢肿瘤。为找到抗肿瘤活性更好、毒性更低的5-FU衍生物,已作了相当大的努力。其中2’-脱氧-5-氟尿苷(FU-DR)和喃氟啶[1-(2-四氢呋喃基)-5-氟尿嘧啶,即Ftorafur,FT]在实验和临床癌症化疗中都具有很大意义。由于这些化合物的疗效均不理想,现在仍在研究5-FU的新衍生物。本文报道一个新化合物5’-脱氧-5-氟尿苷(5-DFUR,I)的抗肿瘤作用。
Fluorouracil (5-FU) is the first pyrimidine antimetabolite that has a growth inhibitory effect on transplanted tumors. In clinical cancer chemotherapy, 5-FU is mainly used to treat gastrointestinal, liver, pancreas, breast and ovarian tumors. In order to find 5-FU derivatives with better anti-tumor activity and lower toxicity, considerable efforts have been made. Among them, 2’-deoxy-5-fluorouridine (FU-DR) and flurandrifluoride [1- (2- tetrahydrofuryl) -5-fluorouracil, ie Ftorafur, FT] are very large in both experimental and clinical cancer chemotherapy significance. Because of the poor efficacy of these compounds, new derivatives of 5-FU are still being studied. This article reports the antitumor effect of a novel compound, 5’-deoxy-5-fluorouridine (5-DFUR, I).