论文部分内容阅读
为了解Ｈｐ长期感染是否促进胃粘膜萎缩、肠上皮化生和异型增生的形成与发展，对首次胃镜检查诊断为慢性胃炎而不伴有肠化生和异型增生的１２０例Ｈｐ阳性患者和８７例Ｈｐ阴性患者进行内镜随访。随访时间３～８年，平均４．８年，随访次数２－１０次，活检组织进行Ｈｐ检查、病理学检查和ＡｇＮＯＲｓ，银染及ＰＣＮＡ免疫组化染色。结果Ｈｐ阳性患者其慢性萎缩性胃炎、肠化生、Ⅲ型肠化生和异型增生的发生率显著高于Ｈｐ阴性患者，Ｈｐ阳性胃粘膜ＰＣＨＡ标记指教和ＡｇＮＯＲｓ数也显著高于Ｈｐ阴性胃粘膜。表明Ｈｐ感染可能通过刺激胃粘膜细胞的过度增殖、更新加快，促进萎缩性胃炎和肠化生的形成与发展，从而增加患胃癌的危险性。
To understand whether long-term Hp infection promotes the formation and development of gastric mucosal atrophy, intestinal metaplasia and dysplasia, 120 patients with Hp positive diagnosed with chronic gastritis for the first time without gastritis and dysplasia were enrolled, and 87 Hp-negative patients underwent endoscopic follow-up. The follow-up time ranged from 3 to 8 years, averaged 4.8 years. The number of follow-up was 2-10 times. Hp examination, histopathological examination and AgNORs, silver staining and PCNA immunohistochemical staining were performed. Results The incidence of chronic atrophic gastritis, intestinal metaplasia, type Ⅲ intestinal metaplasia and dysplasia in Hp positive patients was significantly higher than that in Hp negative patients. PCHA labeling and AgNORs number in Hp positive gastric mucosa were also significantly higher than those in Hp negative gastric mucosa . Hp infection may indicate that it may increase the risk of gastric cancer by stimulating the excessive proliferation of gastric mucosal cells, accelerating the update, promoting the formation and development of atrophic gastritis and intestinal metaplasia.