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目的:观察艾迪注射液联合放化疗治疗中晚期肺癌的临床疗效。方法:将符合纳入标准的80例中晚期肺癌患者随机分为观察组与对照组,每组40例。对照组以PF方案(DDP 25 mg·m-2d 1～3,5-FU 750 mg·m-2d 1～5)化疗2周。第3周改用TP方案(TAX 135 mg·m-2d 1,DDP 25 mg·m-2d 1～3)。同时采用三维适形放疗,5次/周,连续2周。观察组在开始化疗的同时给予艾迪注射液静脉滴注,2次/d。两组疗程均为4周。结果:完全缓解率观察组为52.50%,对照组为35.00%;总有效率观察组为95.00%,对照组为77.50%,治疗组高于对照组(P<0.05)。两组给药后食欲、睡眠、日常活动、精神状态、情绪、与人交往、生活兴趣等方面均较治疗前明显改善(P<0.05),且治疗组改善优于对照组(P<0.05)。两组患者主要的不良反应为骨髓抑制和恶心、厌食,尤其以皮疹、白细胞、血红蛋白、血小板减少为主,无肾功能损害,两组不良反应发生率无显著差异。结论:艾迪注射液联合FP,TP序贯化疗联合放疗治疗中晚期肺癌临床疗效显著,能显著改善生活质量。
Objective: To observe the clinical effect of Aidi injection combined with radiotherapy and chemotherapy in the treatment of advanced lung cancer. Methods: A total of 80 patients with advanced lung cancer who met the inclusion criteria were randomly divided into observation group and control group, 40 cases in each group. The control group was treated with PF regimen (DDP 25 mg · m-2d 1 ~5,5-FU 750 mg · m-2d 1 ~ 5) for 2 weeks. The third week to TP program (TAX 135 mg · m-2d 1, DDP 25 mg · m-2d 1 ~ 3). At the same time using three-dimensional conformal radiotherapy, 5 times / week for 2 weeks. The observation group was given intravenous infusion of Aidi Injection at the same time as chemotherapy, twice a day. Two courses of treatment were 4 weeks. Results: The complete response rate was 52.50% in the observation group and 35.00% in the control group. The total effective rate was 95.00% in the observation group and 77.50% in the control group. The treatment group was higher than the control group (P <0.05). The appetite, sleep, daily activities, mental state, emotion, interaction with people and interest in life of the two groups were significantly improved after treatment (P <0.05), and the treatment group improved better than the control group (P <0.05) . The main adverse reactions of the two groups were myelosuppression, nausea and anorexia, especially rash, leucocyte, hemoglobin and thrombocytopenia, with no renal impairment. The incidence of adverse reactions in the two groups showed no significant difference. Conclusion: Aidi injection combined with FP, TP sequential chemotherapy combined with radiotherapy in the treatment of advanced lung cancer clinical efficacy was significant, can significantly improve the quality of life.