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由药物直接或间接损害肝细胞而引起的肝功能受损,统称为药源性肝病。肝脏是人体内重要的解毒器官。由于肝脏微粒体内存在着药酶,故可催化很多药物在肝脏内进行的化学反应,如氧化、还原、水解、结合、脱羟基、脱氨基、脱羧基等。代谢反应的产物大多变成无害物质排出体外;但也有一些药物或代谢产物会造成肝细胞损害。在组织学上,肝细胞的急性损害主要分为肝细胞毒型和胆汁郁积型两大类。前者可呈现肝细胞坏
By the direct or indirect damage to liver cells caused by liver damage, collectively referred to as drug-induced liver disease. The liver is an important detoxifying organ in the body. Due to the presence of drug enzymes in liver microsomes, it can catalyze many chemical reactions in the liver such as oxidation, reduction, hydrolysis, binding, dehydroxylation, deamination, decarboxylation and the like. Most of the metabolic reaction products become harmless substances excreted; but there are also some drugs or metabolites can cause liver cell damage. In histology, acute liver cell damage is mainly divided into hepatotoxicity and cholestasis type two categories. The former can show liver cell damage