临床统计表明,原发性肝癌(主要是肝细胞癌,HCC)患者以男性为多,男女之比在国内资料为6.3:1。据国外报道,在伴有肝硬化的原发性肝癌患者中,男女之比为11:1。自70年代发现肝腺瘤的发生与口服避孕药密切相关以后,有许多作者报告用人工合成的雌激素和雄激素皆能诱发大鼠肝腺瘤和肝细胞癌。这些研究提示性激素至少可以影响肝脏恶性肿 Clinical statistics show that the number of patients with primary liver cancer (mainly hepatocellular carcinoma, HCC) is male, and the ratio of male to female in domestic data is 6.3:1. According to foreign reports, the ratio of males and females in primary liver cancer patients with cirrhosis is 11:1. Since the discovery of hepatic adenomas in the 1970s was closely related to oral contraceptives, many authors have reported that artificially synthesized estrogens and androgens can induce hepatic adenomas and hepatocellular carcinomas in rats. These studies suggest that sex hormones can at least affect the liver malignancy