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甲状腺过氧化物酶（ＴＰＯ）是甲状腺微粒体的抗原成分。在纯化抗原建立测定抗ＴＰＯ抗体ＥＬＩＳＡ法的基础上，并对抗ＴＰＯ与其他自身抗体的伴随关系作了研究。发现除自身免疫性甲状腺病有较高阳性率外，ＳＬＥ等患者抗ＴＰＯ检出率也很高（１０％～５２．１％），且抗ＴＰＯ阳性者，抗核抗体等其他自身抗体的阳性率也高达３０．８％～９５．２％。抗ＴＰＯ抗体与其他自身抗体的相关系数ｒ＝０．７４６７（Ｐ＜０．０１）。
Thyroid peroxidase (TPO) is an antigenic component of thyroid microsomes. Based on the purified anti-TPA antibody assay and the association between TPO and other autoantibodies, In addition to the higher positive rate of autoimmune thyroid disease, the detection rate of anti-TPO in patients with SLE was also high (10% -52.1%), and positive for other autoantibodies against TPO positive and antinuclear antibodies The rate is as high as 30.8% ~ 95.2%. The correlation coefficient of anti-TPO antibody with other autoantibodies was 0.7467 (P <0.01).