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目的:研究丙型肝炎病毒(HCV)感染者在慢性致病过程中抗HVR1抗体的变化规律。方法:分别利用融合HVR1抗原和多靶点HVR1抗原组合包被酶联板,采用间接酶联免疫法,检测不同阶段慢性HCV感染者体内HVR1抗体存在情况及HVR1抗体的异质程度。结果:在42份无临床症状、41份慢性肝病变、38份肝硬化患者中HVR1抗体的检出率分别为90.5%、95.1%和94.7%,并无显著差异(P>0.05);而这3组患者血清中HVR1抗体异质程度分别为5.39±3.75、11.74±3.29和10.61±4.09;慢性肝病变和肝硬化患者组的抗体异质程度要显著高于急性患者组(P<0.01)。结论:HCV慢性感染的严重程度与HVR1抗体的异质程度相关,但与HVR1抗体的存在情况无关。
Objective: To study the variation of anti-HVR1 antibody in the pathogenesis of chronic hepatitis C virus (HCV) infection. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to coat the HVR1 antigen and the multi-target HVR1 antigen respectively. The indirect HVR1 antibody was used to detect the presence of HVR1 antibody and HVR1 antibody heterogeneity in patients with chronic HCV infection at different stages. Results: The detection rates of HVR1 antibodies in 42 patients with no clinical symptoms, 41 chronic liver diseases and 38 patients with cirrhosis were 90.5%, 95.1% and 94.7%, respectively. There was no significant difference (P> 0.05) The heterogeneity of HVR1 antibody in the three groups were 5.39 ± 3.75, 11.74 ± 3.29 and 10.61 ± 4.09, respectively. The level of antibody heterogeneity in patients with chronic liver disease and cirrhosis was significantly higher than that in acute patients (P <0.01). CONCLUSIONS: The severity of chronic HCV infection is related to the heterogeneity of HVR1 antibodies, but not to the presence of HVR1 antibodies.