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大部分尿道感染(UTI)病例并无细菌侵入血,但可有全身反应,细菌刺激尿道粘膜引起全身反应的机理尚未有研究。白介素-6(IL-6)生物活性谱与急性肾盂肾炎发作时一致,IL-6是一种内源性致热原,可诱发肝脏合成C-反应性蛋白等急性反应物。IL-6从尿道感染病灶经血流到达肝脏和体温调节中枢,也许可以引起或促进UTI病人的全身反应。本文旨在分析UTI病人是否有IL-6激活,从而评价IL-6对急性肾盂肾炎和无症状菌尿的局部和全身性反应。
Most cases of urinary tract infections (UTI) did not invade the bloodstream of bacteria, but systemic reactions may occur. The mechanism by which bacteria stimulate systemic reactions of the urethral mucosa has not been studied. The bioactive spectrum of interleukin-6 (IL-6) is consistent with the onset of acute pyelonephritis. IL-6 is an endogenous pyrogen and induces the acute synthesis of C-reactive proteins in the liver. IL-6 transfusion from the site of urinary tract infection to the liver and to the body’s thermoregulatory center may cause or contribute to systemic reactions in UTI patients. This article aims to analyze whether UTI patients have IL-6 activation to assess the local and systemic response of IL-6 to acute pyelonephritis and asymptomatic bacteriuria.