Improvement of lipid profile and atherogenic index in rat treated with Cymbopogon citratus Stapf wat

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OBJECTIVE To investigate the effects of Cymbopogon citratus Stapf water extract(CCS)on lipid profile,atherogenic index and antioxidant enzymes in Sprague-Dawley rats.METHODS Rats aged eight weeks(250±20)g were orally administered with CCS at 250 and 500mg·kg-1·d-1 for one month.RESULTS Administration of CCS extract to rats caused significant decrease of serum total cholesterol,triglycerides and LDL levels,whereas,the HDL level was increased compared with untreated rats(P<0.05).Moreover,the CCS extract showed a significant decreased atherogenic index in comparison with untreated rats(P<0.05).Furthermore,serum activities of superoxide dismutases and catalase were also improved in rats treated with CCS.This was consistent with decrease of serum thiobarbituric acid reactive substance.CONCLUSION The present study provides evidence that CCS water extract provides a benefit effect on serum lipid and atherogenic index and exhibits antioxidant effect in vivo. OBJECTIVE To investigate the effects of Cymbopogon citratus Stapf water extract (CCS) on lipid profile, atherogenic index and antioxidant enzymes in Sprague-Dawley rats. METHODS Rats aged eight weeks (250 ± 20) g were orally administered with CCS at 250 and 500 mg · kg-1 · d-1 for one month .RESULTS Administration of CCS extract to rats caused significant decrease of serum total cholesterol, triglycerides and LDL levels, while, the HDL level was increased compared with untreated rats (P <0.05) .Moreover, the CCS extract showed a significant decreased atherogenic index in comparison with untreated rats (P <0.05) .Furthermore, serum activities of superoxide dismutases and catalase were also improved in rats treated with CCS.This was consistent with decrease of serum thiobarbituric acid reactive substance. CONCLUSION The present study provides evidence that CCS water extract provides a benefit effect on serum lipid and atherogenic index and exhibits antioxidant effect in vivo.
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