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目的:观察复方中药高位保留灌肠联合微波脐周照射治疗肝硬化腹水并自发性细菌性腹膜炎(SBP)的疗效。方法:将85例肝硬化腹水并SBP患者随机分成治疗组43例和对照组42例,两组均抗感染、支持、对症治疗,治疗组在常规治疗基础上用复方中药高位保留灌肠联合微波脐周照射。观察两组患者腹痛、腹胀、腹泻、发热症状持续的时间、治疗前后临床与实验室相关指标变化情况。结果:治疗组总有效率为86.4%,对照组为67.4%,差异有统计学意义(P<0.05)。治疗组腹痛、腹胀、腹泻、发热症状持续的时间明显少于对照组(P<0.05);治疗组24 h尿量增加、腹围、腹水白细胞、血浆降钙素原(PCT)及内毒素(LPS)下降程度明显大于对照组(P<0.05)。结论:对肝硬化腹水合并SBP患者在常规治疗基础上给予复方中药高位保留灌肠联合微波脐周照射,能有效改善临床症状,缩短病程。
Objective: To observe the curative effect of compound traditional Chinese medicine high retention enema and microwave umbilical irradiation on cirrhotic ascites and spontaneous bacterial peritonitis (SBP). Methods: Eighty-five cases of cirrhotic patients with ascites and SBP were randomly divided into treatment group (n = 43) and control group (n = 42). Both groups were anti-infective, supportive and symptomatic. The treatment group was treated with compound Chinese medicine high retention enema and microwave navel Weekly exposure. The duration of abdominal pain, bloating, diarrhea and fever were observed in both groups. The changes of clinical and laboratory related indexes before and after treatment were observed. Results: The total effective rate was 86.4% in the treatment group and 67.4% in the control group, the difference was statistically significant (P <0.05). The duration of abdominal pain, abdominal distension, diarrhea and fever in treatment group was significantly shorter than that in control group (P <0.05). The urine output of abdominal cavity, ascites, PCT and endotoxin LPS) decreased significantly more than the control group (P <0.05). Conclusion: Patients with cirrhosis and ascites combined with SBP on the basis of conventional treatment given compound high retention enema with microwave umbilical irradiation, can effectively improve the clinical symptoms and shorten the course of the disease.