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目的在动物模型中探讨电钻振动诱导听力减退的机制和可能的血迷路屏障变化。方法用电磁振荡器在5只豚鼠听泡上产生可重复的振动,其振动频率为250 Hz,用复合动作电位评估其听功能,振动后3小时至4 天用4．7特斯拉磁共振成像分析其血迷路屏障变化。静脉注射T1增强剂Gadolinium-diethylenetriaminepentaacetate- bismethylamide(Gd-DTPA-BMA)作为血迷路屏障的示踪剂。结果振动诱导平均听力损失40 dB HL,在振动后立即测试的耳蜗中,其中阶摄取Gd-DTPA-BMA,提示血迷路屏障通透性增加。在振动后2天至4天的动物中,其中阶内无Gd-DTPA-BMA摄取。结论 250 Hz振动使血路屏障通透性增加是使导致听力减退的原因之一。其通透性的变化为一个可逆的过程。
OBJECTIVE: To investigate the mechanism of electric drill vibration-induced hearing loss and possible changes in blood-labyrinth barrier in animal models. Methods Electromagnetic oscillators were used to generate repeatable vibrations on 5 guinea pigs with a vibrational frequency of 250 Hz. The auditory function was evaluated by composite action potentials. The Tesla magnetic resonance was performed 3 to 4 days after vibration Imaging analysis of changes in the blood labyrinth barrier. Intravenous injection of T1 enhancer Gadolinium-diethylenetriaminepentaacetate-bismethylamide (Gd-DTPA-BMA) as a tracer of the vagal bleeding barrier. Results Vibration induced an average hearing loss of 40 dB HL, of which Gd-DTPA-BMA was taken in the cochlea immediately after vibration, suggesting increased permeability of the blood labyrinth barrier. There was no Gd-DTPA-BMA uptake in the animals from 2 days to 4 days after shaking. CONCLUSION 250 Hz vibration increases the permeability of the blood-barrier to one of the causes of hearing loss. The change of permeability is a reversible process.