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天然生物活性物质是指从生物合成的天然物质中发现生物活性和选择先导化合物来开发新药。天然生物活性物质是各种生物在生命活动过程中产生的化学物质。其中有的对生物本身有重要生理功能,例如内源激素;另一些则是生理生化过程中产生的次生代谢产物,它们作为“副产物”或“废料”积存体内或被排出体外,对该生物本身不再有明显的生理作用,但却可能对別种生物引起生理活性,如毒性作用、生理调节作用等。
Natural bioactive substances refer to the discovery of biological activity from biosynthetic natural substances and the selection of leading compounds to develop new drugs. Natural bioactive substances are chemicals produced by various living things during their life activities. Some of them have important physiological functions to the organism itself, such as endogenous hormones; others are secondary metabolites produced during physiological and biochemical processes that accumulate in vivo or are excreted as “by-products” or “waste” In vitro, the biological itself no longer has a significant physiological role, but it may cause other types of biological activity, such as toxic effects, physiological regulation and so on.