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目的:制备吡喹酮固体脂质纳米粒(PZQ-SLN),并考察其理化性质。方法:以山嵛酸甘油酯和乙酸丁酯为脂质材料,超声分散法制备PZQ-SLN,透射电镜观察纳米粒形态,测定其粒径、Zeta电位和药物包封率,并进行体外释放试验及考察样品的稳定性。结果:所得脂质纳米粒为类圆球状,粒径分布较均匀。样品粒径为(100±21)nm,包封率为(79.3±0.69)%,平均Zeta电位值为—66.3mV。药物体外释放符合Weibull方程。4℃放置3mo后粒径、包封率和Zeta电位均无明显变化。结论:制备的PZQ-SLN理化性质较为理想,能使药物缓慢释放。4℃条件下贮存比较稳定。
OBJECTIVE: To prepare pZQ-SLN (solid lipid nanoparticles) and investigate its physicochemical properties. Methods: PZQ-SLN was prepared by ultrasonic dispersion method using glycerol behenate and butyl acetate as lipid materials. The morphology of nanoparticles was observed by transmission electron microscopy. The particle size, Zeta potential and entrapment efficiency were measured and the in vitro release test And examine the stability of the sample. Results: The obtained lipid nanoparticles were spheroidal and the particle size distribution was more uniform. The sample size was (100 ± 21) nm, the entrapment efficiency was (79.3 ± 0.69)%, and the average Zeta potential was -66.3mV. Drug in vitro release in line with the Weibull equation. After 3moment at 4 ℃ for 3mo, the particle size, encapsulation efficiency and Zeta potential did not change obviously. Conclusion: The prepared PZQ-SLN has better physical and chemical properties, which can release the drug slowly. 4 ℃ storage conditions more stable.