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阿克拉霉素B(Aclacinomycin B,ACM-B)是一种新型蒽环类抗肿瘤抗生素阿克拉霉素A(ACM-A)的同系物,其对实验性肿瘤,特别是Lewis肺癌具有较好的疗效。对于它的作用机理、急性、亚急性毒性,中国医学科学院药物研究所以及四川抗菌素工业研究所等单位已做了较详细的研究。本文主要介绍ACM-B在大鼠体内分布、排泄的规律。
Aclacinomycin B (ACM-B) is a homolog of aclacinomycin A (ACM-A), a novel anthracycline antitumor antibiotic that has good activity against experimental tumors, especially Lewis lung cancers Efficacy. For its mechanism of action, acute, subacute toxicity, Institute of Materia Medica, Chinese Academy of Medical Sciences and Sichuan Institute of Antibiotics and other units have done a more detailed study. This article mainly introduces the distribution and excretion of ACM-B in rats.