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目的:分析药物不良反应(Adeversedrugreaction,ADR)与药源性疾病(Drug induced Diseases,DID)发生特点,总结防治对策。方法:以医院上报的药物不良反应报告842份作为研究对象,分析发生特征,总结防治对策。结果:899份不良反应,40~49岁患者最多,其次为50~59岁,男女性别比0.82∶1,40~49岁男女性别比最低为0.60∶1,≤16岁、≥80岁男性不良反应发生例高于女性;严重不良反应3例;涉及药物174种,抗感染药物涉及品种最多,注射液、粉针剂均占40%以上,合计90%以上,静脉滴注占85%以上;前6位累及系统与器官为皮肤及其附件、胃肠道损害、中枢及外周神经系统、用药部位、全身性、心血管循环系统。结论:药物不良反应与药源性疾病发生与年龄、性别、给药方法有关,相关药品种类多,需加强抗感染药物使用监管,加强输液管理,建立健全不良反应与药源性疾病监测体系。
Objective: To analyze the occurrence characteristics of ADR and DID, and summarize the control strategies. Methods: 842 reports of adverse drug reactions reported by the hospital were taken as research objects, the characteristics of occurrence were analyzed, and the control measures were summarized. Results: Among the 899 adverse reactions, the patients aged 40-49 years were the most frequently followed by those aged 50-59. The odds ratio of male to female was 0.82:1. The incidence of the reaction was higher than that of the female. There were 3 cases of serious adverse reactions. Of the 174 drugs involved, anti-infectives involved the most varieties. Injection and injection accounted for over 40%, accounting for more than 90% 6 involved in the system and organs of the skin and its annexes, gastrointestinal damage, central and peripheral nervous system, medication site, systemic, cardiovascular system. Conclusion: Adverse drug reactions and drug-induced diseases are related to age, sex and drug administration methods. There are many kinds of related drugs. It is necessary to strengthen the supervision of the use of anti-infective drugs, strengthen the infusion management and establish a sound monitoring system of adverse reactions and drug-induced diseases.