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目的:探讨超微铁皮石斛对脾虚便秘的疗效。方法:将42只实验小鼠随机分为模型组、正常组和治疗组(铁皮石斛传统剂量组、超微全量组、超微50%量组、超微25%量组),每组7只。对模型组和治疗组大鼠采用灌胃番泻叶水煎液7d后控制饮食、饥饱失常8d的方法制备小鼠脾虚便秘模型。造模结束后,模型组和正常组灌胃无菌水,治疗组分别灌胃给药铁皮石斛传统汤剂、超微全量汤剂、超微50%量汤剂和超微25%量汤剂,共7d。观察小鼠的毛发、活力和粪便等一般特征的变化情况;分别于造模开始前、治疗开始前和治疗完成后称量小鼠体质量,比较各组小鼠经铁皮石斛治疗前后体质量变化及体质量变化率。结果:模型组脾虚便秘症状无显著改善,体质量变化和体质量变化率较正常组低,各治疗组的脾虚便秘症状均有不同程度的改善。结论:铁皮石斛传统汤剂、超微全量汤剂和超微50%量汤剂对脾虚便秘均有很好的疗效。
Objective: To investigate the effect of Dendrobium candidum on constipation of spleen deficiency. Methods: Forty-two experimental mice were randomly divided into model group, normal group and treatment group (traditional dose group of Dendrobium officinale, superfine total amount group, super 50% dose group, super 25% dose group) . The rats in model group and treatment group were given spleen-deficiency constipation model by intragastric administration of senna decoction for 7 days and then dietary control and normal diet for 8 days. After modeling, the model group and the normal group were given gavage with sterile water. The treatment group were given gavage of traditional decoction of Dendrobium officinale, superfine total decoction, superfine 50% decoction and super 25% decoction , A total of 7d. The changes of general characteristics such as hair, vitality and excrement of mice were observed. Before and after the start of treatment, the body weight of mice was weighed and compared before and after treatment. The body weight of mice in each group was compared before and after treatment with Dendrobium officinale And body mass change rate. Results: The symptoms of constipation in spleen deficiency model group had no significant improvement, the change of body weight and the rate of change of body weight were lower than those in normal group. The constipation symptoms of spleen deficiency in each treatment group improved to some extent. Conclusion: Dendrobium officinale traditional decoction, superfine decoction and super 50% decoction have good effect on constipation of spleen.