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目的探讨同步放化疗联合中药治疗局部晚期宫颈癌的临床疗效及其对生活质量的影响。方法选取2010年7月至2015年7月间山东省临朐县人民医院收治的120例Ⅱb~Ⅲb期宫颈癌患者,采取随机数字表法分为观察组和对照组,每组各60例。观察组患者接受中药联合同步放化疗治疗,对照组患者仅接受单纯同步放化疗治疗。比较两组患者治疗4周后贫血、血小板下降和腹泻不良反应的发生率以及治疗有效率和生活质量评分。结果观察组患者贫血、血小板下降、腹泻、骨髓抑制、慢性放射性肠炎和慢性放射性膀胱炎发生率较对照组相比差异无统计学意义(P>0.05)。与对照组比较,观察组患者治疗有效率明显提高,组间差异有统计学意义(P<0.05)。与对照组比较,观察组患者3年和5年生存率均显著提高,复发率显著降低,组间差异有统计学意义(P<0.05)。与治疗前比较,治疗4周后观察组和对照组患者焦虑自我评价得分均降低,生活质量评分均升高,但观察组改善情况较对照组更为明显,组间差异有统计学意义(P<0.05)。结论采用中药联合同步放化疗治疗局部晚期宫颈癌的临床疗效突出,相比于单纯同步放化疗具有诸多优势,可作为一种理想方法应用于临床。
Objective To investigate the clinical efficacy of concurrent chemoradiotherapy combined with traditional Chinese medicine in the treatment of locally advanced cervical cancer and its impact on quality of life. Methods A total of 120 patients with stage Ⅱb-Ⅲb cervical cancer who were treated in Lintao County People’s Hospital of Shandong Province from July 2010 to July 2015 were randomly divided into observation group and control group with 60 cases in each group. Patients in the observation group received traditional Chinese medicine combined with concurrent radiotherapy and chemotherapy, and patients in the control group received only simple concurrent chemoradiotherapy. The incidences of anemia, thrombocytopenia, and adverse reactions to diarrhea were compared between the two groups after 4 weeks of treatment, as well as treatment effectiveness and quality of life scores. Results The incidence of anemia, thrombocytopenia, diarrhea, myelosuppression, chronic radiation enteritis and chronic radiation cystitis in the observation group were not significantly different from those in the control group (P> 0.05). Compared with the control group, the observation group patients treatment efficiency was significantly improved, the difference between groups was statistically significant (P <0.05). Compared with the control group, the 3-year and 5-year survival rates of the observation group were significantly increased, the recurrence rate was significantly reduced, the difference between the two groups was statistically significant (P <0.05). Compared with those before treatment, anxiety self-evaluation score and quality of life scores of observation group and control group decreased after 4 weeks of treatment, but the improvement in observation group was more obvious than that of control group (P <0.05). Conclusions The clinical efficacy of combined chemoradiotherapy with traditional Chinese medicine in the treatment of locally advanced cervical cancer is outstanding. Compared with simple concurrent chemoradiotherapy, it has many advantages and can be used as an ideal method in clinical practice.