论文部分内容阅读
本文研究了自由饮食(FPD)、低蛋白饮食(LPD)及LPD 加用必需氨基酸(LPD+EAA)对慢性肾衰大鼠肾功能及腹腔巨噬细胞Fc 受体功能的影响。结果表明;(1)LPD 组及LPD+EAA 组经20天治疗可显著降低向尿素氮水平,FPD 组实验前后无明显变化;(2)LPD 组体重下降明显,LPD+EAA组维持治疗前水平,而FPD 组显著增加。说明LPD+EAA 治疗可以维持体重、改善LPD 疗法的营养不良状态;(3)LPD 组腹腔巨噬细胞Fc 受体EA 花环形成率明显低于FPD 组和LPD+EAA 组,而LPD+EAA 组与FPD 组无显著差异。提示EAA 治疗可改善单纯LPD 所致的腹腔巨噬细胞Fc 受体功能缺陷,对防止因低蛋白饮食引起的继发感染可能有一定作用。
This study investigated the effects of free diet (FPD), low protein diet (LPD), and LPD plus essential amino acids (LPD+EAA) on renal function and Fc receptor function of peritoneal macrophages in rats with chronic renal failure. The results showed that: (1) LPD group and LPD+EAA group could significantly reduce the level of urea nitrogen after 20 days of treatment, while FPD group had no significant changes before and after the experiment; (2) LPD group had significant weight loss, and LPD+EAA group maintained the pre-treatment level. While the FPD group increased significantly. This indicated that LPD+EAA treatment could maintain body weight and improve the malnutrition status of LPD therapy; (3) LPD group peritoneal macrophage Fc receptor EA garland formation rate was significantly lower than FPD group and LPD+EAA group, while LPD+EAA group There was no significant difference in the FPD group. It is suggested that EAA therapy can improve the function of peritoneal macrophage Fc receptors caused by LPD alone, and it may play a role in preventing secondary infection caused by low protein diet.