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近年来的研究表明,多种疾病的组织损伤均与氧自由基代谢有关,氧自由基及其所引发的脂质过氧化反应在肾脏疾病中发挥着重要的作用,其代谢产物MDA及抗氧化系统SOD浓度的变化均可客观地反映脂质过氧化反应程度及抗氧化能力的强弱。本文旨在通过检测急、慢性肾功能不全患者血浆MDA和SOD浓度变化来探讨氧自由基在急、慢性肾功能不全发病中的作用。
In recent years, studies have shown that tissue damage in a variety of diseases are related to the metabolism of oxygen free radicals, oxygen free radicals and lipid peroxidation caused by it play an important role in kidney disease, its metabolites MDA and antioxidant System SOD concentration changes can objectively reflect the degree of lipid peroxidation and antioxidant capacity. This article aims to explore the role of oxygen free radicals in the pathogenesis of acute and chronic renal insufficiency by detecting plasma concentrations of MDA and SOD in patients with acute and chronic renal insufficiency.