目的:探讨辛伐他汀联合运动训练治疗慢性阻塞性肺疾病(COPD)稳定期合并代谢综合征患者的临床疗效,为临床治疗提供指导。方法:按照随机数字表法将2013年9月-2015年3月我院收治的COPD稳定期合并代谢综合征患者分为A、B组和对照组,A组患者在常规治疗的基础上联合辛伐他汀和运行训练,B组患者在常规治疗的基础上以辛伐他汀治疗,对照组患者仅以常规治疗。治疗后6个月,比较三组患者的临床治疗效果。结果:A、B组治疗后的血清白细胞介素-6(IL-6)白细胞介素-8(IL-8)以及肿瘤坏死因子-α(TNF-α)水平低于治疗前,差异有统计学意义(P<0.05),对照组治疗后的IL-6、IL-8及TNF-α水平与治疗前差异无统计学意义(P>0.05),治疗后A组的IL-6、IL-8及TNF-α水平明显低于B组,差异有统计学意义(P<0.05)。A组的胰岛素抵抗指数(HOMA-IR)低于B组、对照组,差异有统计学意义(P<0.05);A、B组的颈-股动脉脉搏波速度(CFPWV)低于对照组,差异有统计学意义(P<0.05)。A、B组治疗后的改良医学研究委员会量表(m MRC)低于对照组,A组m MCR低于B组,差异有统计学意义(P<0.05),A、B组治疗后的6 min步行距离(6MWD)高于对照组,A组6MWD高于B组,差异有统计学意义(P<0.05)。结论:辛伐他汀联合运动训练能明显降低COPD稳定期合并代谢综合征患者的炎症性反应,改善患者的胰岛素抵抗和大动脉弹性,提高临床治疗效果。 Objective: To investigate the clinical efficacy of simvastatin combined with exercise training in the treatment of stable COPD patients with chronic obstructive pulmonary disease (COPD) and provide guidance for clinical treatment. Methods: The patients with stable COPD and metabolic syndrome admitted to our hospital from September 2013 to March 2015 were randomly divided into A, B and control groups according to the random number table method. Patients in group A received combined Xin Statin and run training, patients in group B were treated with simvastatin on a regular basis and patients in control group were treated only routinely. Six months after treatment, the clinical effects of the three groups were compared. Results: The levels of serum IL-6, IL-8 and tumor necrosis factor-α (TNF-α) in group A and group B after treatment were lower than those before treatment The levels of IL-6, IL-8 and TNF-α in the control group were not significantly different from those before treatment (P> 0.05). After treatment, the levels of IL-6 and IL- 8 and TNF-α levels were significantly lower than those in group B, the difference was statistically significant (P <0.05). The insulin resistance index (HOMA-IR) in group A was lower than that in group B and the control group (P <0.05). The neck-to-femoral artery pulse wave velocity (CFPWV) in group A and group B was lower than that in control group The difference was statistically significant (P <0.05). A, B group after treatment, the modified Medical Research Council scale (m MRC) was lower than the control group, m MCR A group was lower than the B group, the difference was statistically significant (P <0.05), A, B group after treatment 6 min (6MWD) was higher than that of the control group. The 6MWD of group A was higher than that of group B, the difference was statistically significant (P <0.05). Conclusion: Simvastatin combined with exercise training can significantly reduce the inflammatory response in stable COPD patients with metabolic syndrome, improve insulin resistance and arterial elasticity, and improve the clinical curative effect.