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目的：探讨人巨细胞病毒活动性感染与冠心病发生发展的关系。方法2010年6月至2011年2月确诊为冠心病的患者61例设为冠心病组，另选同期体检健康者44例设为健康对照组，其他疾病患者48例设为其他疾病对照组，采用捕获酶联免疫吸附法检测所有纳入对象血清中巨细胞病毒免疫球蛋白M （HCM V‐IgM ），并比较分析HCM V‐IgM阳性率。结果冠心病组、健康对照组和其他疾病对照组的 HCM V‐IgM 阳性率分别为8．20％、2．27％和4．17％，冠心病组与其他两组的HCMV‐IgM阳性率分别比较，差异均无统计学意义（P＞0．05）。结论尚不能认为冠心病与巨细胞病毒活动性感染相关，仍需要进一步研究证实。“,”Objective To investigate the correlation between coronary artery disease and human cytomegalov‐irus (HCMV) active infection .Methods A total of 61 patients with coronary artery disease ,treated during Jun .2010 and Feb .2011 ,were enrolled as coronary artery disease group ,44 cases of healthy subjects were enrolled as healthy control group ,and 48 patients with other diseases were enrolled as other diseases group .HCMV immunoglobulin M (HCMV‐IgM) was tested ,and the positive rates of HCMV‐IgM were compared among the three groups .Results The positive rate of HCMV‐IgM in coronary artery disease group ,healthy control group and other diseases group was 8 .20% ,2 .27% and 4 .17% respectively .Compared with healthy control group and other diseases group ,the positive rate of coronary artery disease group was without significant differences (P>0 .05) .Conclusion It still could not presumed that coronary heart disease might be related with HCMV active infection .