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目的:观察复方甘草酸苷联合苦参碱治疗慢性乙型肝炎的临床疗效。方法:慢性乙型肝炎患者92例随机分为治疗组46例,对照组46例。在常规治疗基础上,对照组给予苦参碱注射液150 mg+质量分数10%葡萄糖注射液250 mL静脉滴注,1次/d;治疗组苦参碱用法用量同对照组,复方甘草酸苷注射液40 mL+质量分数5%葡萄糖注射液250 mL静脉滴注,1次/d。2组疗程均为3个月。比较2组治疗前、后血清丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素水平,HBsAg、HBeAg、HBV-DNA阴转率及疗效。结果:2组治疗后血清丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素水平均较治疗前下降(P<0.01),治疗组下降优于对照组(P<0.01);治疗组HBV-DNA阴转率69.6%,对照组37.0%,2组比较差异有统计学意义(P<0.05);治疗组总有效率95.7%,对照组63.0%,2组比较差异有统计学意义(P<0.05)。结论:复方甘草酸苷联合苦参碱治疗慢性乙型肝炎疗效优于单用苦参碱。
Objective: To observe the clinical efficacy of compound glycyrrhizin combined with matrine in the treatment of chronic hepatitis B Methods: Ninety-two patients with chronic hepatitis B were randomly divided into treatment group (n = 46) and control group (n = 46). On the basis of routine treatment, the control group was given intravenous infusion of 150 mg matrine and 10% glucose injection 250 mg once daily for 12 days. The dosage of matrine in the treatment group was the same as that of the control group. The compound glycyrrhizin injection Liquid 40 mL + mass fraction of 5% glucose injection 250 mL intravenous infusion, 1 time / d. The two groups were treated for 3 months. The serum levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, HBsAg, HBeAg and HBV-DNA in the two groups before and after treatment were compared. Results: Serum levels of alanine aminotransferase, aspartate aminotransferase and total bilirubin decreased after treatment in both groups (P <0.01), but decreased in the treatment group (P <0.01). The levels of HBV -DNA negative conversion rate was 69.6% in the control group and 37.0% in the control group. The difference between the two groups was statistically significant (P <0.05). The total effective rate was 95.7% in the treatment group and 63.0% in the control group, with significant difference between the two groups <0.05). Conclusion: Compound glycyrrhizin combined with matrine in the treatment of chronic hepatitis B is better than single matrine.