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已经充分证实,在充血性心力衰竭病人中发生一些电解质的临床显著改变。镁离子是机体ATP代谢所必需,又称“能量离子”。体内许多酶系统(约300个以上),其中许多存在于心血管系统的激活需要镁离子。有迅速增加的证据表明,镁对心衰病人的存活是个主要危险因素。动物实验显示,镁参予动脉粥样硬化过程的一些阶段,虽然在人类这种过程有些更为复杂。镁离子在心衰和各种心律失常中起极为重要的作用。通常用于治疗心衰的一些药物(利尿剂、洋地黄类),不仅能显著影响细胞镁离子内环境稳定,也显著影响钾离子内环境稳定。这些药物有汞剂、噻嗪类和袢利尿剂。也有报告指出,低镁血症常见于洋地黄中毒。另一方面,已经证实有些药物具有
It has been well established that some clinically significant changes in electrolytes occur in patients with congestive heart failure. Magnesium ions are necessary for the body’s ATP metabolism, also known as “energy ions.” Many enzymes in the body (about 300+), many of which are required for the activation of the cardiovascular system, require magnesium ions. There is rapidly increasing evidence that magnesium is a major risk factor for the survival of heart failure patients. Animal experiments show that magnesium participates in some stages of the atherosclerotic process, although this process is somewhat more complicated in humans. Magnesium ions play an extremely important role in heart failure and various arrhythmias. Some commonly used drugs for the treatment of heart failure (diuretics, digitalis) can not only significantly affect the stability of cells within the magnesium ion environment, but also significantly affect the stability of potassium ion environment. These drugs have mercury, thiazides and loop diuretics. It has also been reported that hypomagnesemia is common in digitalis poisoning. On the other hand, some drugs have been confirmed