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至今,人们已意识到血小板增多是炎症性肠病(IBD)活动期的一种标志,且是发生全身性血栓栓塞的一种可能诱发因素。 作为炎症细胞的血小板,能直接引起炎症反应。将血小板提取物注入健康人皮肤,可发生强烈炎症反应,且可持续数小时,而注入中性粒细胞及嗜碱性细胞的提取物则无此反应。活化的血小板可释放一系列炎性介质,如血小板活化因子(PAF)、血栓素(Tα)12-HETE、血小板
To date, it has been recognized that thrombocytosis is a hallmark of the active phase of inflammatory bowel disease (IBD) and is a possible predisposing factor for systemic thromboembolism. As a platelet of inflammatory cells, can directly cause inflammation. Injecting platelet extract into healthy human skin, a strong inflammatory reaction can occur that lasts for several hours, whereas neutrophil and basophil-infused extracts have no response. Activated platelets release a range of inflammatory mediators such as platelet-activating factor (PAF), thrombospondin (Tα) 12-HETE, platelets