目的:分析骨科清洁伤口手术预防性用抗菌药情况。方法:179例骨科清洁伤口手术预防性应用抗菌药的用药时间、用药种类、用药频度以及联合用药进行了调查、分析。结果:无用药史19例。口服用药25例。注射用药135例(包括麻醉开始时和手术中用药38例),其中用单一用药68例,二联用药59例,三联用药8例,而麻醉前预防性用药为0例。结论:临床医师应提高术前预防性用抗菌药意识,严格术中无菌操作,避免滥用抗菌药。 OBJECTIVE: To analyze the preventive antibacterials used in orthopedic surgery. Methods: 179 cases of orthopedic clean wounds for prophylactic use of antibacterial drugs were treated, the type of medication, the frequency of medication and the combination of drugs were investigated and analyzed. Results: No medication history in 19 cases. Oral medication in 25 cases. There were 135 cases of injection (including the beginning of anesthesia and the 38 cases of surgery). Among them, 68 cases were treated with single drug, 59 cases with dual drug and 8 cases with triple drug, while prophylactic drug was 0 case before anesthesia. Conclusion: Clinicians should raise awareness of prophylactic antimicrobials preoperatively, strictly during aseptic operation and avoid abuse of antimicrobial agents.