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目的 :了解青少年卵巢恶性肿瘤临床特点及预后的关系。方法 :收集本院1985年～1994年间治疗的20岁以下青少年卵巢恶性肿瘤28例 ,并作了5年的跟踪随访。结果 :本组青少年卵巢恶性肿瘤中生殖细胞肿瘤24例(85.71%) ,上皮性肿瘤3例(10.71 %) ,性索间质肿瘤1例(3.57 %)。10例采用保留生育功能手术 ,其中3例治疗后正常分娩 ,6例采用卵巢癌根治术 ,10例采用肿瘤细胞减灭术 ,5年生存率分别为60 %、50 %、0%。术后24例患者辅以化疗 ,使用VAC方案6例 ,用BEP或BVP方案18例 ,5年生存率分别为16.67%、50%。结论 :对青少年卵巢恶性肿瘤应尽可能采用保留生育功能手术 ,恶性生殖细胞肿瘤术后最好采用BEP/BVP方案化疗6疗程 ,可明显改善预后。
Objective: To understand the clinical characteristics and prognosis of adolescent ovarian cancer. Methods: Twenty-eight cases of adolescent ovarian cancer under 20 years of age treated in our hospital from 1985 to 1994 were collected and followed up for 5 years. Results: There were 24 germ cell tumors (85.71%), 3 epithelial tumors (10.71%) and 1 (3.57%) stromal tumors in adolescent ovarian malignant tumors. Ten cases were treated with fertility-preserving surgery. Three of them were given normal delivery after operation, six cases were treated with radical mastectomy and 10 cases were treated with cytoreductive surgery. The 5-year survival rates were 60%, 50% and 0% respectively. After operation, 24 patients were treated with chemotherapy, 6 patients received VAC and 18 patients received BEP or BVP. The 5-year survival rates were 16.67% and 50% respectively. Conclusion: Adolescent ovarian malignancies should be used as far as possible to retain reproductive function surgery, malignant germ cell tumors after the best use of BEP / BVP regimen of 6 courses of chemotherapy, can significantly improve the prognosis.