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目的探讨长时间游泳对大鼠心肌线粒体渗透的影响。方法采用实验对比研究方法。结果90min运动组与对照组相比,心肌线粒体的还原型谷胱甘肽(GSH)的含量无显著性差异,游离钙(Fca2+)长高;长时间力竭运动组与对照组相比,心肌线粒体的丙二醛(MDA)显著升高,巯基(-SH)和还原型谷胱甘肽(GSH)显著减少,游离钙(Fca2+)含量也明显降低。结论力竭运动后线粒体疏基、谷胱甘肽含量的下降引起线粒体渗透性转运可能是运动性疲劳的主要原因。
Objective To investigate the effect of prolonged swimming on myocardial mitochondrial permeability in rats. Methods Experimental contrast study method. Results Compared with the control group, the content of reduced glutathione (GSH) in myocardial mitochondria of 90min exercise group was not significantly different and that of free calcium (Fca2 +) was longer in 90min exercise group than in control group. Compared with control group, The content of malondialdehyde (MDA) in mitochondria was significantly increased, and the contents of sulfhydryl (-SH) and reduced glutathione (GSH) and the content of free calcium (Fca2 +) were significantly decreased. Conclusions The mitochondrial permeability and mitochondrial glutathione decrease after exhaustive exercise may be the main reason of exercise-induced fatigue.