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曾报道,用缺乏维生素B1的食物饲养大鼠会出现学习记忆障碍,其机制是引起脑内胆碱能神经及抑生长素神经变性。加味温胆汤具有改善阿尔茨海默型痴呆模型老龄大鼠学习障碍的作用。本次从行为药理学方面探讨了加味温胆汤对缺乏维生素B1大鼠学习记忆障碍的作用。并且,为明确该方作用与胆碱能神经的关系,以显微测光分析系统装置观察了脑内胆碱乙酰转移酶(ChAT)的浓度。
It has been reported that rats fed with diets deficient in vitamin B1 have learning and memory impairments, the mechanism of which is to cause neurodegeneration of cholinergic nerves and somatostatin in the brain. Modified Wendan Decoction can improve the learning disabilities in aged rats with Alzheimer’s dementia. From the aspect of behavioral pharmacology, the effect of Jiawei Wendan Decoction on learning and memory impairment in rats lacking vitamin B1 was discussed. And, in order to clarify the relationship between the side effects and cholinergic nerves, the concentration of choline acetyltransferase (ChAT) in the brain was observed using a microphotometric analysis system.