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采用一维红外光谱(FTIR)并结合二阶导数谱技术,对9个不同厂家的六味地黄丸进行了快速无损的鉴别研究。结果表明,它们在一维谱图上差别不显著,而在高分辨率的二阶导数谱中,它们之间具有明显的差异,可以达到类同制剂的鉴别和质量监控。结论:一维红外光谱和二阶导数谱相结合可快速有效地分析和鉴别不同厂家生产的六味地黄丸。六味地黄丸是否以熟地黄入药,将影响其药效与质量。若以生地黄入药,那么单糖含量少,在1020 cm~(-1)附近吸收峰弱,但氨基酸含量多,出现了3676 cm~(-1)吸收峰。此外,吸收峰777 cm~(-1)也可作为熟地黄含量的另1个重要指标。该方法快速、简便、直观、可靠,适用于药物的鉴定。
Using one-dimensional infrared spectroscopy (FTIR) combined with second derivative spectroscopy, nine different manufacturers of Liu Wei Di Huang Wan for rapid and nondestructive identification. The results show that they are not significant difference in the one-dimensional spectra, while in the second-order derivative spectra of high resolution, there is a clear difference between them, which can achieve the identification and quality control of analogues. Conclusion: The combination of one-dimensional infrared spectrum and the second derivative spectrum can quickly and effectively analyze and identify Liu Wei Di Huang Wan produced by different manufacturers. Liu Wei Di Huang Wan Rehmannia into medicine, will affect its efficacy and quality. If rehmanniae is used as medicine, the content of monosaccharide is low, the absorption peak is weak around 1020 cm ~ (-1), but the content of amino acid is large, and the peak of 3676 cm ~ (-1) appears. In addition, the absorption peak of 777 cm -1 can also be used as another important index of Rehmannia glutinosa content. The method is rapid, simple, intuitive and reliable and is suitable for the identification of drugs.