自1962年美国 Lesher 等报道了萘啶酸以来,许多学者致力于研究开发这类药物,尤其近年来研究得比较活跃,取得了较快进展,出现的一些氟取代的新品种,其抗菌作用与疗效已大大超过萘啶酸等同类药物,甚至达到或超过第三代头孢菌素类的抗菌作用.到目前为止已合成数百种吡啶酮酸类化合物,但用于临床或进入临床研究者仅十多种.根 Since the report of Nalidixic Acid by Lesher et al. In 1962, many scholars have devoted themselves to the research and development of these drugs. In recent years, many scholars have been active in research and have made rapid progress. Some new fluorine-substituted varieties have been found to have antimicrobial activity Curative effect has greatly surpassed nalidixic acid and other similar drugs, and even reached or exceeded the third-generation cephalosporins antimicrobial effect.Has been hundreds of synthetic pyridone acids, but for clinical or into clinical research only More than ten kinds of roots